Description

Doxycycline Tablets (100mg)

Manufactured by: Healthy Life Pharma Pvt. Ltd. (WHO-GMP Certified)

Exported by: Healthy Inc (Star Export House)

1. Product Introduction

Healthy Life Pharma Pvt. Ltd. is a specialized Manufacturer of Doxycycline Tablets in India. Doxycycline is a broad-spectrum Tetracycline Antibiotic known for its long half-life and high lipid solubility, allowing it to penetrate deep into tissues. It is a first-line treatment for Acne Vulgaris, Chlamydia, Lyme Disease, and is the gold standard for Malaria Prophylaxis for travelers.

We offer Contract Manufacturing (Third Party) services for this versatile antibiotic. Doxycycline is highly acidic and can cause severe esophageal irritation if the tablet dissolves in the throat. Our WHO-GMP certified facility in Mumbai utilizes advanced Film Coating technology to ensure the tablet is swallowed easily and dissolves only in the stomach. We offer both Doxycycline Hyclate (standard) and Doxycycline Monohydrate (gentler on the stomach) formulations. Healthy Inc manages the export logistics, supplying dermatology clinics, travel medicine centers, and pharmacy chains across the USA, UK, Australia, and Africa.

2. Product Specifications

3. Manufacturing Technology

Safety for the esophagus and stability for the shelf.

• The Manufacturer: Healthy Life Pharma Pvt. Ltd.

  • Esophageal Safety: Doxycycline Hyclate is acidic (pH 2-3). We apply a specialized Slip-Coat (Opadry) to the tablets. This reduces friction, ensuring the tablet slides down the esophagus quickly to the stomach, preventing “pill esophagitis” (ulcers in the throat).

  • Dispersible Options: For pediatric (over 8 years) or geriatric use, we can manufacture Dispersible Tablets (DT) that dissolve in a spoon of water, eliminating swallowing difficulties.

  • Light Protection: Tetracyclines darken when exposed to light. We use opaque blister films and amber coating pigments to ensure the product remains stable throughout its shelf life.

• The Exporter: Healthy Inc

  • Travel Packs: We specialize in “Malaria Travel Kits” (e.g., blister packs of 50 tablets) designed for long-term prophylaxis travelers.

4. Quality Assurance

We adhere to strict Pharmacopoeial standards:

• Dissolution: We test release profiles to ensure >85% of the drug releases within 30 minutes.

• Assay: We confirm the potency is strictly within 90-120% of the label claim (Tetracyclines often have wider limits due to potency calculations).

• Impurity Profiling: We strictly monitor for degradation products (4-Epianhydrotetracycline) which can be toxic to the kidneys (Fanconi syndrome).

5. Why Use Doxycycline?

The deep-penetrating antibiotic.

• Mechanism: Doxycycline binds reversibly to the 30S ribosomal subunit of the bacteria. This blocks the binding of tRNA, preventing the addition of new amino acids to the peptide chain, thus stopping protein synthesis (Bacteriostatic).

• Key Indications:

  • Acne: Kills C. acnes bacteria and reduces inflammation (low dose).

  • STIs: Chlamydia, Gonorrhea, and Syphilis (in penicillin-allergic patients).

  • Respiratory: Pneumonia (Atypical) and Bronchitis.

  • Malaria: Prevention of malaria in travelers to drug-resistant areas.

6. Export and Regulatory Support

We streamline the registration process for our B2B partners:

• Dossier Support: We offer CTD and ACTD Dossiers for quick registration.

• Certificates: Free Sale Certificate (FSC), COPP (WHO-GMP), and COA.

• Logistics: Efficient shipping via Air or Sea (FOB Mumbai / CIF).

7. Frequently Asked Questions

• Q: Who manufactures Doxycycline Tablets?

  A: Healthy Life Pharma Pvt. Ltd. manufactures them in India.

• Q: Is it Vibramycin?

  A: Vibramycin is the brand name (Pfizer). We manufacture the Generic Equivalent (Doxycycline), which acts exactly the same.

• Q: Why can’t I lie down after taking it?

  A: Warning: If the pill gets stuck in your throat, it acts like acid and can burn a hole in your esophagus. Always take it with a full glass of water and stay upright for 30 minutes.

• Q: Does it cause sunburn?

  A: Yes. It causes Photosensitivity. You will burn very easily in the sun. Wear sunscreen and protective clothing.

CLINICAL PHARMACOLOGY & SAFETY INFORMATION

(For Registered Medical Practitioners & Patient Reference)

8. Dosage and Administration

• General Infection: 200mg on Day 1, then 100mg daily.

• Acne: 100mg once or twice daily.

• Malaria Prophylaxis: 100mg daily (start 1-2 days before travel, continue daily during, and 4 weeks after return).

• Administration: Swallow with a full glass of water. Take with food/milk if gastric irritation occurs (though milk slightly reduces absorption, it is permitted with Doxycycline unlike other tetracyclines).

9. Side Effects and Precautions

• Gastrointestinal: Nausea, vomiting, diarrhea, esophagitis.

• Dermatologic: Severe Photosensitivity (sunburn), rash.

• Teeth Staining: Contraindicated in pregnancy and children < 8 years old. It binds to calcium and causes permanent yellow-gray staining of developing teeth.

• Intracranial Hypertension: Rare risk of increased pressure in the brain (headache/vision changes).

10. Storage Instructions

• Store below 25°C in a dry place.

• Protect from light. (Degraded tetracyclines can be toxic).