Description

Diethylcarbamazine Tablets (50mg / 100mg / 300mg)

Manufactured by: Healthy Life Pharma Pvt. Ltd. (WHO-GMP Certified)

Exported by: Healthy Inc (Star Export House)

1. Product Introduction

Healthy Life Pharma Pvt. Ltd. is a specialized Manufacturer of Diethylcarbamazine Citrate (DEC) Tablets in India. DEC is the World Health Organization’s (WHO) drug of choice for the treatment and global elimination of Lymphatic Filariasis (Elephantiasis). It is an essential anti-helminthic (anti-worm) drug that is also used to treat Tropical Pulmonary Eosinophilia and Loiasis (African Eye Worm).

We offer Contract Manufacturing (Third Party) services for this high-volume public health medicine. Diethylcarbamazine is highly hygroscopic (absorbs moisture rapidly). Our WHO-GMP certified facility in Mumbai utilizes specialized humidity-controlled processing zones and moisture-proof packaging to ensure the tablets do not degrade or become sticky in tropical storage conditions. Healthy Inc is a key supplier to global Mass Drug Administration (MDA) programs, government tenders, and NGOs across Africa, India, and Southeast Asia.

2. Product Specifications

3. Manufacturing Technology

Stability for tropical climates.

• The Manufacturer: Healthy Life Pharma Pvt. Ltd.

  • Hygroscopic Management: DEC Citrate avidly absorbs water from the air. We manufacture at < 40% Relative Humidity (RH) and use specific non-hygroscopic excipients (like Dibasic Calcium Phosphate) to stabilize the tablet core.

  • Mass Production: We have high-speed tableting lines capable of producing millions of tablets per shift to meet the massive demands of national filariasis elimination campaigns.

  • Content Uniformity: We ensure rigorous mixing protocols so that every 50mg or 100mg tablet contains the precise dose needed to effectively kill microfilariae without causing toxicity.

• The Exporter: Healthy Inc

  • MDA Packaging: We specialize in “Community Health Worker Kits” and bulk hospital packs designed for efficient distribution during mass drug administration drives.

4. Quality Assurance

We adhere to strict Pharmacopoeial standards:

• Dissolution: We test release profiles to ensure >75% of the drug releases within 45 minutes.

• Assay: We confirm the potency is strictly within 95-105% of the label claim.

• Microbial Limits: We ensure the product is free from pathogens, maintaining safety for large populations.

5. Why Use Diethylcarbamazine?

The cornerstone of Filariasis elimination.

• Mechanism: DEC has a dual action. First, it alters the surface membrane of the Microfilariae (larval worms), making them susceptible to the host’s immune system (phagocytosis). Second, it inhibits the worm’s arachidonic acid metabolism, causing paralysis. It is highly effective against microfilariae and also kills some adult worms.

• Key Indications:

  • Lymphatic Filariasis: Treatment and prophylaxis of infection caused by Wuchereria bancrofti and Brugia malayi.

  • Tropical Pulmonary Eosinophilia (TPE): Rapidly clears the asthmatic symptoms caused by filarial immune reaction in the lungs.

  • Loiasis: Treatment of infection by the Loa loa worm.

6. Export and Regulatory Support

We streamline the registration process for our B2B partners:

• Dossier Support: We offer CTD and ACTD Dossiers for quick registration.

• Certificates: Free Sale Certificate (FSC), COPP (WHO-GMP), and COA.

• Logistics: Efficient shipping via Air or Sea (FOB Mumbai / CIF).

7. Frequently Asked Questions

• Q: Who manufactures Diethylcarbamazine Tablets?

  A: Healthy Life Pharma Pvt. Ltd. manufactures them in India.

• Q: Is it Hetrazan or Banocide?

  A: Hetrazan and Banocide are brand names. We manufacture the Generic Equivalent (DEC Citrate), which works exactly the same.

• Q: Does it have side effects?

  A: Yes, the “Mazzotti Reaction”. When the worms die, they release toxins that cause fever, headache, and muscle pain. This is actually a sign the drug is working.

• Q: Is it safe for pregnant women?

  A: Generally Avoided. WHO guidelines often recommend delaying treatment until after pregnancy during mass campaigns, although it is not known to be teratogenic.

CLINICAL PHARMACOLOGY & SAFETY INFORMATION

(For Registered Medical Practitioners & Patient Reference)

8. Dosage and Administration

• Lymphatic Filariasis: 6 mg/kg body weight daily (divided doses) for 12 days.

• Tropical Pulmonary Eosinophilia: 6 mg/kg daily for 21 days.

• Mass Drug Administration (Prophylaxis): Single annual dose (often combined with Albendazole).

• Administration: Take after meals to reduce stomach upset.

9. Side Effects and Precautions

• Reaction to Dying Worms: Fever, headache, dizziness, nausea, and lymph node swelling. (Treat with antipyretics/antihistamines).

• Contraindication (Onchocerciasis): WARNING: Do NOT use in patients with River Blindness (Onchocerca volvulus). Rapid killing of microfilariae in the eye can cause blindness (Mazzotti reaction).

• Renal Impairment: Reduce dose in patients with kidney failure.

10. Storage Instructions

• Store below 30°C in a dry place.

• Keep container tightly closed. (Protect from moisture).