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Pyrimethamine Tablets

Pyrimethamine Tablets

PYRIMETHAMINE TABLEST IP 25 MG
EACH UNCOATED TABLET CONTAINS
PYRIMETHAMINE IP 25 MG
EXCIPENTS

Usage: – Treat a serious parasite infection

Category: – Antimalarial drugs

Therapeutic category: – Antimalarial

SKU: Pyrimethamine Tablets Categories: , , , , , , Tags: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

Description

Pyrimethamine Tablet (25mg)

Manufactured by Healthy Life Pharma Pvt. Ltd. | Exported by Healthy Inc

1. Product Introduction Healthy Life Pharma Pvt. Ltd. is a specialized manufacturer of Pyrimethamine Tablet in India. This potent antiprotozoal medication is a cornerstone in the treatment of Malaria and Toxoplasmosis. We produce high-purity tablets that ensure consistent bioavailability. Our facility adheres to strict WHO-GMP standards. Therefore, we guarantee efficacy in critical infectious disease management. Healthy Inc manages our global exports and NGO tenders.

2. Product Specifications | Parameter | Specification | | :— | :— | | Product Name | Pyrimethamine Tablet | | Generic Name | Pyrimethamine USP / BP / IP | | Strength | 25mg | | Dosage Form | Uncoated Tablet | | Standard | USP / BP / IP Compliant | | Therapeutic Class | Antimalarial / Antiprotozoal | | Shelf Life | 36 Months | | Packaging | 10×10 Blister / 1000s Bulk Jar |

3. Manufacturing Pyrimethamine Tablet We divide our operations to ensure specialized focus.

  • The Manufacturer: Healthy Life Pharma Pvt. Ltd. First, Healthy Life Pharma handles manufacturing. We operate a WHO-GMP certified plant in Mumbai. Pyrimethamine acts by inhibiting enzymes in parasites. Therefore, dosage precision is critical. We use high-precision compression machines to ensure every 25mg tablet contains the exact amount of active ingredient. We also ensure the tablet hardness is optimized to survive transport to tropical regions while still dissolving rapidly in the stomach.

  • The Exporter: Healthy Inc Second, Healthy Inc manages international trade. This division handles logistics for Pyrimethamine Tablet. We have extensive experience supplying this drug to Malaria-endemic regions in Africa and Southeast Asia. We are familiar with the documentation required for Ministry of Health tenders and global aid programs.

4. Quality Assurance We test every batch rigorously.

  • Assay Verification: We use HPLC testing. This confirms the drug potency is exact.

  • Dissolution: We test how the tablet releases the drug. Consistent release is vital for maintaining therapeutic blood levels to kill parasites.

  • Microbial Limits: We ensure the product is free from contamination, which is crucial for immunocompromised patients taking this for Toxoplasmosis.

5. Why Use Pyrimethamine Tablet? This drug targets the reproductive cycle of parasites.

  • Mechanism: It interferes with the regeneration of tetrahydrofolic acid (essential for DNA/RNA synthesis) in the parasite.

  • Effect: It stops the parasite from reproducing, allowing the immune system to clear the infection.

Key Indications:

  • Malaria: Treatment of uncomplicated malaria (usually in combination with Sulfadoxine) and prophylaxis for travelers.

  • Toxoplasmosis: Treatment of Toxoplasmosis (caused by Toxoplasma gondii), often used with Sulfadiazine.

  • Pneumocystis Pneumonia: Second-line treatment / prophylaxis.

6. Export and Regulatory Support We provide complete documentation for registration.

  • Dossier: We offer CTD and ACTD formats.

  • Certificates: We supply the Free Sale Certificate (FSC) and COPP.

  • Logistics: We ship via FOB Mumbai or CIF.

7. Frequently Asked Questions

  • Q: Who manufactures Pyrimethamine Tablet?A: Healthy Life Pharma Pvt. Ltd. manufactures them in India.

  • Q: Is this used alone for Malaria?A: It is rarely used alone due to resistance. It is most often used in combination with a sulfonamide (like Sulfadoxine).

  • Q: Do you supply the combination (Pyrimethamine + Sulfadoxine)?A: Yes, we manufacture both the single Pyrimethamine tablet and the combination tablet.

CLINICAL PHARMACOLOGY & SAFETY INFORMATION (For Registered Medical Practitioners & Patient Reference)

8. Dosage and Administration

  • Malaria Prophylaxis: Typically 25mg once weekly.

  • Toxoplasmosis: High doses (e.g., 50mg to 75mg daily) used in combination with Sulfadiazine.

  • Administration: Take with food to minimize gastric irritation (nausea/vomiting).

  • Supplementation: Patients on high doses should take Leucovorin (Folinic Acid) to prevent bone marrow suppression.

9. Side Effects and Precautions

  • Common Side Effects: Nausea, vomiting, and loss of appetite (anorexia).

  • Severe Reactions: Skin rashes (Stevens-Johnson Syndrome) can occur, especially when combined with sulfonamides.

  • Hematology: Can cause megaloblastic anemia due to folic acid deficiency. Regular blood counts are recommended during prolonged therapy.

  • Contraindications: Megaloblastic anemia due to folate deficiency.

10. Storage Instructions

  • Store below 30°C in a dry place.

  • Light Sensitive: Protect from direct light.

  • Keep out of reach of children.

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